Ustekinumab is a fully humanised IgG1 therapeutic monoclonal antibody used for the treatment of Crohn’s disease, ulcerative colitis, plaque psoriasis and psoriatic arthritis. It targets cytokines IL-12 and IL-23 which are involved in immune-mediated inflammatory disorders.
The IDKmonitor Ustekinumab Free Anti-drug Antibody ELISA measures free antibodies against ustekinumab (e.g. STELARA®). This assay enables the reliable determination of free, unbound anti-drug antibodies; therefore it is ideal for therapy monitoring when a measurable ustekinumab concentration is not expected, or the unbound fraction of anti-drug antibodies is required, for example shortly before the next infusion. In combination with the drug level determination, the IDKmonitor® Ustekinumab Free Anti-drug Antibody ELISA supports the monitoring and optimisation of therapy.