Detecting free anti-etanercept antibodies in serum and plasma
IDKmonitor Etanercept Free Anti-drug Antibody ELISA is a quantitative assay that detects human antibodies against etanercept in EDTA plasma and serum samples. Etanercept is a human therapeutic monoclonal antibody used to monitor treatment for chronic rheumatic diseases such as rheumatoid arthritis. This recombinant protein has the potential to induce humoral immune responses and lead to anti-drug antibody formation; a major cause of loss of response to the drug. These anti-drug antibodies can bind and neutralise the drug, accelerating its clearance and reducing its efficacy.