Determination of free anti-vedolizumab antibodies
Vedolizumab is a recombinant protein used to treat Crohn’s disease and ulcerative colitis. This protein can induce humoral immune responses and lead to anti-drug antibody formation which is a major cause of loss of drug response. The IDKmonitor Vedolizumab Free Anti-drug ELISA kit is a microplate-based quantitative sandwich ELISA for the determination of free anti-vedolizumab antibodies in plasma or serum samples. Detecting high levels of free anti-vedolizumab antibodies in patients when the drug level is low (undetectable or sub-therapeutic) may indicate poorer long-term outcomes and suggest the need to switch treatment.
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